Cyclooxygenase-2 polymorphisms and susceptibility to colorectal cancer: a meta-analysis.

ABSTRACT:

Purpose

Four polymorphisms, -765G>C, -1195G>A, 8473T>C, and Val511Ala, in the cyclooxygenase-2 (COX-2) gene were identified to be associated with colorectal cancer (CRC) risk. However, the results are inconsistent. The objective of this meta-analysis was to evaluate the association between these four polymorphisms and the risk of CRC.

Materials and methods

All eligible case-control studies published up to December 2012 on the association between the four polymorphisms of COX-2 and CRC risk were identified by searching PubMed and Web of Science. The CRC risk associated with the four polymorphisms of the COX-2 gene was estimated for each study by odds ratio (OR) together with its 95% confidence interval (CI), respectively.

Results

A total of 15 case-control studies were

SUBMITTER: Wang J 

PROVIDER: S-EPMC3809860 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature