Chemisorption assembly of Au nanorods on mercaptosilanized glass substrate for label-free nanoplasmon biochip.

ABSTRACT: The fabrication of a localized surface plasmon resonance nanosensor in a chip based format that utilizes Au nanorods (GNRs) as the optical transducer were systematically studied. (3-mercaptopropyl)trimethoxysilane (MPTMS) modified glass substrate offers GNR deposition with maximal sensitivity to local refractive index changes, which subsequently results in better optical recognition of receptor-analyte binding. Kinetics governing the mass transport and chemisorption of nanorods from bulk to solid surface can be dynamically controlled in a predictable fashion. We demonstrate that slight aggregation induced by a low ionic strength (5 mM NaCl) can facilitate the nanorod assembly to result in a dense, well-distributed surface monolayer. In high ionic media (e.g. 40-80 mM), anions present elect

SUBMITTER: Wang Y 

PROVIDER: S-EPMC3809993 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature