Early time-dependent dynamic changes of TBET and GATA3 mRNA expressions in patients with acute coronary syndrome.

ABSTRACT:

Background

T-box expressed in T cells (TBET) and guanine adenine thymine adenine sequence-binding protein 3 (GATA3) play important roles in the differentiation of Th1 and Th2 subsets, which contributes to the progression of acute coronary syndrome (ACS).

Objective

This study aimed to investigate the temporal change of TBET/GATA3 mRNA ratio in ACS.

Methods

Thirty-three patients suspected of ACS with symptom onset within 24 hours were recruited. Blood samples were taken after arrival at the emergency department and at hourly intervals until the 6th hour. The mRNA expressions of TBET and GATA3 were quantified by a real-time RT-qPCR.

Results

The TBET/GATA3 mRNA ratio was elevated dramatically in patients with acute myocardial infarction (AMI) and exhibited biphasic

SUBMITTER: Rainer TH 

PROVIDER: S-EPMC3810123 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature