Downregulation of nuclear-encoded genes of oxidative metabolism in dialyzed chronic kidney disease patients.

ABSTRACT:

Background

Mitochondria, essential eukaryotic cells organelles defined as the "powerhouse of the cell" because of their ability to produce the vast majority of energy necessary for cellular metabolism, may have a primary role in the oxidative stress-related intracellular machinery associated to chronic kidney disease (CKD).

Methods

To better assess this research assumption, we decided to study the key factors regulating mitochondrial oxidative metabolism in CKD patients in peritoneal dialysis (PD, n = 15) using several bio-molecular methodologies.

Results

RT-PCR experiments demonstrate that the expression level of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) and nuclear respiratory factor-1 (NRF-1), two genes primarily involved in mito

SUBMITTER: Zaza G 

PROVIDER: S-EPMC3810143 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature