Replication study for reported SNP associations with breast cancer survival.

ABSTRACT:

Purpose

Nine previously reported associations between single nucleotide polymorphisms (SNPs) and breast cancer outcomes from the Shanghai Breast Cancer Study (Stage 1) were further evaluated in relation to disease-free survival (DFS) and overall survival (OS) among 5,192 additional breast cancer patients (Stage 2).

Methods

Hazard ratios (HR) and 95% confidence intervals (CI) were calculated by proportional hazards regression in models adjusted for age, disease stage, estrogen and progesterone receptor status, and treatment regimens.

Results

Two SNPs had generally consistent results and significant associations with OS in combined analyses. Compared to women with MMP7 rs11225297 AA genotypes, OS was moderately better for women with AT genotypes (HR: 0.8, 95% CI: 0.7-1.

SUBMITTER: Beeghly-Fadiel A 

PROVIDER: S-EPMC3810152 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature