Pathway analyses identify TGFBR2 as potential breast cancer susceptibility gene: results from a consortium study among Asians.

ABSTRACT:

Background

The TGF-β signaling pathway plays a significant role in the carcinogenic process of breast cancer.

Methods

We systematically evaluated associations of common variants in TGF-β signaling pathway genes with breast cancer risk using a multistage, case-control study among Asian women.

Results

In the first stage, 341 single-nucleotide polymorphisms with minor allele frequencies ≥ 0.05 across 11 genes were evaluated among 2,926 cases and 2,380 controls recruited as a part of the Shanghai Breast Cancer Genetics Study (SBCGS). In the second stage, 20 SNPs with promising associations were evaluated among an additional 1,890 cases and 2,000 controls from the SBCGS. One variant, TGFBR2 rs1078985, had highly consistent and significant associations with breast cancer ri

SUBMITTER: Ma X 

PROVIDER: S-EPMC3810157 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature