Contribution of higher risk genes and European admixture to Crohn's disease in African Americans.

ABSTRACT:

Background

African Americans (AAs) are an admixed population of West African (WA) and European ancestry (EA). Crohn's disease (CD) susceptibility genes have not been established. We therefore evaluated the contribution of European admixture and major established risk genes to AA CD.

Methods

Ninety-seven admixture informative markers were genotyped for ancestry estimates using STRUCTURE. Overall, 354 AA CD cases and 354 ethnicity-matched controls were genotyped for total 21 single nucleotide polymorphisms (SNPs) in ATG16L1, NOD2, IBD5, IL23R and IRGM by TaqMan or direct sequencing. Association was evaluated by logistic regression, adjusted for ancestry.

Results

Mean EA was similar among the CD cases and controls (20.9% and 20.4%, respectively, P = 0.58). No significant

SUBMITTER: Wang MH 

PROVIDER: S-EPMC3810419 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature