TNFRSF10B polymorphisms and haplotypes associated with increased risk of death in non-small cell lung cancer.

ABSTRACT: Presently, there are few validated biomarkers that can predict survival or treatment response for non-small cell lung cancer (NSCLC) and most are based on tumor markers. Biomarkers based on germ line DNA variations represent a valuable complementary strategy, which could have translational implications by subclassifying patients to tailored, patient-specific treatment. We analyzed single nucleotide polymorphisms (SNPs) in 53 inflammation-related genes among 651 NSCLC patients. Multivariable Cox proportional hazard models, adjusted for lung cancer prognostic factors, were used to assess the association of genotypes and haplotypes with overall survival. Four of the top 15 SNPs associated with survival were located in the TNF-receptor superfamily member 10b (TNFRSF10B) gene. The T-allele of t

SUBMITTER: Schabath MB 

PROVIDER: S-EPMC3810840 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature