GIM3E: condition-specific models of cellular metabolism developed from metabolomics and expression data.

ABSTRACT:

Motivation

Genome-scale metabolic models have been used extensively to investigate alterations in cellular metabolism. The accuracy of these models to represent cellular metabolism in specific conditions has been improved by constraining the model with omics data sources. However, few practical methods for integrating metabolomics data with other omics data sources into genome-scale models of metabolism have been developed.

Results

GIM(3)E (Gene Inactivation Moderated by Metabolism, Metabolomics and Expression) is an algorithm that enables the development of condition-specific models based on an objective function, transcriptomics and cellular metabolomics data. GIM(3)E establishes metabolite use requirements with metabolomics data, uses model-paired transcriptomics data to

SUBMITTER: Schmidt BJ 

PROVIDER: S-EPMC3810847 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature