A-clustering: a novel method for the detection of co-regulated methylation regions, and regions associated with exposure.

ABSTRACT:

Motivation

DNA methylation is a heritable modifiable chemical process that affects gene transcription and is associated with other molecular markers (e.g. gene expression) and biomarkers (e.g. cancer or other diseases). Current technology measures methylation in hundred of thousands, or millions of CpG sites throughout the genome. It is evident that neighboring CpG sites are often highly correlated with each other, and current literature suggests that clusters of adjacent CpG sites are co-regulated.

Results

We develop the Adjacent Site Clustering (A-clustering) algorithm to detect sets of neighboring CpG sites that are correlated with each other. To detect methylation regions associated with exposure, we propose an analysis pipeline for high-dimensional methylation data in w

SUBMITTER: Sofer T 

PROVIDER: S-EPMC3810849 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature