Effect of high-dose vs standard-dose multivitamin supplementation at the initiation of HAART on HIV disease progression and mortality in Tanzania: a randomized controlled trial.

ABSTRACT:

Context

Large randomized trials have previously shown that high-dose micronutrient supplementation can increase CD4 counts and reduce human immunodeficiency virus (HIV) disease progression and mortality among individuals not receiving highly active antiretroviral therapy (HAART); however, the safety and efficacy of such supplementation has not been established in the context of HAART.

Objective

To test the hypothesis that high-dose multivitamin supplementation vs standard-dose multivitamin supplementation decreases the risk of HIV disease progression or death and improves immunological, virological, and nutritional parameters in patients with HIV initiating HAART.

Design, setting, and participants

A randomized, double-blind, controlled trial of high-dose vs standard-d

SUBMITTER: Isanaka S 

PROVIDER: S-EPMC3811009 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature