Evolution of Pseudomonas aeruginosa virulence as a result of phage predation.

ABSTRACT: The rapid increase in the emergence of antibiotic-resistant bacteria has attracted attention to bacteriophages for treating and preventing bacterial infections. Bacteriophages can drive the diversification of Pseudomonas aeruginosa, giving rise to phage-resistant variants with different phenotypes from their ancestral hosts. In this study, we sought to investigate the effect of phage resistance on cytotoxicity of host populations toward cultured mammalian cells. The library of phage-resistant P. aeruginosa PAO1 variants used was developed previously via experimental evolution of an isogenic host population using phages PP7 and E79. Our results presented herein indicate that the phage-resistant variants developed in a heterogeneous phage environment exhibit a greater ability to impede metab

SUBMITTER: Hosseinidoust Z 

PROVIDER: S-EPMC3811365 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature