Probing 3-hydroxyflavone for in vitro glycorandomization of flavonols by YjiC.

ABSTRACT: The glycosylation of five different flavonols, fisetin, quercetin, myricetin, kaempferol, and 3-hydroxyflavone, was achieved by applying YjiC. 3-Hydroxyflavone was selected as a probe for in vitro glycorandomization of all flavonols using diverse nucleotide diphosphate-d/l-sugars. This study unlocked the possibilities of the glycodiversification of flavonols and the generation of novel compounds as future therapeutics.

SUBMITTER: Pandey RP 

PROVIDER: S-EPMC3811512 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature