Phylogenetic and chemical diversity of a hybrid-isoprenoid-producing streptomycete lineage.

ABSTRACT: Streptomyces species dedicate a large portion of their genomes to secondary metabolite biosynthesis. A diverse and largely marine-derived lineage within this genus has been designated MAR4 and identified as a prolific source of hybrid isoprenoid (HI) secondary metabolites. These terpenoid-containing compounds are common in nature but rarely observed as bacterial secondary metabolites. To assess the phylogenetic diversity of the MAR4 lineage, complementary culture-based and culture-independent techniques were applied to marine sediment samples collected off the Channel Islands, CA. The results, including those from an analysis of publically available sequence data and strains isolated as part of prior studies, placed 40 new strains in the MAR4 clade, of which 32 originated from marine sourc

SUBMITTER: Gallagher KA 

PROVIDER: S-EPMC3811536 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature