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Cloning and heterologous expression of the thioviridamide biosynthesis gene cluster from Streptomyces olivoviridis.


ABSTRACT: Thioviridamide is a unique peptide antibiotic containing five thioamide bonds from Streptomyces olivoviridis. Draft genome sequencing revealed a gene (the tvaA gene) encoding the thioviridamide precursor peptide. The thioviridamide biosynthesis gene cluster was identified by heterologous production of thioviridamide in Streptomyces lividans.

SUBMITTER: Izawa M 

PROVIDER: S-EPMC3811549 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature

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Cloning and heterologous expression of the thioviridamide biosynthesis gene cluster from Streptomyces olivoviridis.

Izawa Masumi M   Kawasaki Takashi T   Hayakawa Yoichi Y  

Applied and environmental microbiology 20130830 22


Thioviridamide is a unique peptide antibiotic containing five thioamide bonds from Streptomyces olivoviridis. Draft genome sequencing revealed a gene (the tvaA gene) encoding the thioviridamide precursor peptide. The thioviridamide biosynthesis gene cluster was identified by heterologous production of thioviridamide in Streptomyces lividans. ...[more]

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