Shell-crosslinked knedel-like nanoparticles induce lower immunotoxicity than their non-crosslinked analogs.

ABSTRACT: The development of stable nanoparticles that can withstand the changing conditions experienced in a biological setting and also be of low toxicity and immunogenicity is of particular importance to address the problems associated with currently utilized nanotechnology-based therapeutics and diagnostics. The use of crosslinked nanoparticles continues to receive special impetus, due to their robust structure and high kinetic stability, and they have recently been shown to induce lower cytotoxicity than their non-crosslinked micellar counterparts. In the current study, poly(acrylamidoethylamine)-block-poly(DL-lactide) (PAEA₉₀-b-PDLLA₄₀) copolymers were synthesized, self-assembled in water to yield nanoscopic polymeric micelles, and the effects of decorating

SUBMITTER: Elsabahy M 

PROVIDER: S-EPMC3811931 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature