Correlated occurrence and bypass of frame-shifting insertion-deletions (InDels) to give functional proteins.

ABSTRACT: Short insertions and deletions (InDels) comprise an important part of the natural mutational repertoire. InDels are, however, highly deleterious, primarily because two-thirds result in frame-shifts. Bypass through slippage over homonucleotide repeats by transcriptional and/or translational infidelity is known to occur sporadically. However, the overall frequency of bypass and its relation to sequence composition remain unclear. Intriguingly, the occurrence of InDels and the bypass of frame-shifts are mechanistically related - occurring through slippage over repeats by DNA or RNA polymerases, or by the ribosome, respectively. Here, we show that the frequency of frame-shifting InDels, and the frequency by which they are bypassed to give full-length, functional proteins, are indeed highly cor

SUBMITTER: Rockah-Shmuel L 

PROVIDER: S-EPMC3812077 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature