Restoration of anterior regeneration in a planarian with limited regenerative ability.

ABSTRACT: Variability of regenerative potential among animals has long perplexed biologists. On the basis of their exceptional regenerative abilities, planarians have become important models for understanding the molecular basis of regeneration. However, planarian species with limited regenerative abilities are also found. Despite the importance of understanding the differences between closely related, regenerating and non-regenerating organisms, few studies have focused on the evolutionary loss of regeneration, and the molecular mechanisms leading to such regenerative loss remain obscure. Here we examine Procotyla fluviatilis, a planarian with restricted ability to replace missing tissues, using next-generation sequencing to define the gene expression programs active in regeneration-permissive and

SUBMITTER: Sikes JM 

PROVIDER: S-EPMC3812084 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature