Transcriptome analysis reveals distinct patterns of long noncoding RNAs in heart and plasma of mice with heart failure.

ABSTRACT:

Objective

To assess the global changes in and characteristics of the transcriptome of long noncoding RNAs (LncRNAs) in heart tissue, whole blood and plasma during heart failure (HF) and association with expression of paired coding genes.

Methods

Here we used microarray assay to examine the transcriptome of LncRNAs deregulated in the heart, whole blood, and plasma during HF in mice. We confirmed the changes in LncRNAs by quantitative PCR.

Results

We revealed and confirmed a number of LncRNAs that were deregulated during HF, which suggests a potential role of LncRNAs in HF. Strikingly, the patterns of expression of LncRNA differed between plasma and other tissue during HF. LncRNA expression was associated with LncRNA length in all samples but not in plasma during HF, wh

SUBMITTER: Li D 

PROVIDER: S-EPMC3812140 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature