Beta lactam monotherapy versus beta lactam-aminoglycoside combination therapy for sepsis in immunocompetent patients: systematic review and meta-analysis of randomised trials.

ABSTRACT:

Objective

To compare beta lactam monotherapy with beta lactam-aminoglycoside combination therapy for severe infections.

Data sources

Medline, Embase, Lilacs, Cochrane Library, and conference proceedings, to 2003; references of included studies; contact with all authors. No restrictions, such as language, year of publication, or publication status.

Study selection

All randomised trials of beta lactam monotherapy compared with beta lactam-aminoglycoside combination therapy for patients without neutropenia who fulfilled criteria for sepsis.

Data selection

Two reviewers independently applied selection criteria, performed quality assessment, and extracted the data. The primary outcome assessed was all cause fatality by intention to treat. Relative risks were pooled

SUBMITTER: Paul M 

PROVIDER: S-EPMC381218 | biostudies-literature | 2004 Mar

REPOSITORIES: biostudies-literature