Cerebral blood flow and gray matter volume covariance patterns of cognition in aging.

ABSTRACT: Advancing age results in altered cognitive and neuroimaging-derived markers of neural integrity. Whether cognitive changes are the result of variations in brain measures remains unclear and relating the two across the lifespan poses a unique set of problems. It must be determined whether statistical associations between cognitive and brain measures truly exist and are not epiphenomenal due solely to their shared relationships with age. The purpose of this study was to determine whether cerebral blood flow (CBF) and gray matter volume (GMV) measures make unique and better predictions of cognition than age alone. Multivariate analyses identified brain-wide covariance patterns from 35 healthy young and 23 healthy older adults using MRI-derived measures of CBF and GMV related to three cognitiv

SUBMITTER: Steffener J 

PROVIDER: S-EPMC3812339 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature