Escherichia coli glutathionylspermidine synthetase/amidase: phylogeny and effect on regulation of gene expression.

ABSTRACT: Glutathionylspermidine synthetase/amidase (Gss) and the encoding gene (gss) have only been studied in Escherichia coli and several members of the Kinetoplastida phyla. In the present article, we have studied the phylogenetic distribution of Gss and have found that Gss sequences are largely limited to certain bacteria and Kinetoplastids and are absent in a variety of invertebrate and vertebrate species, Archea, plants, and some Eubacteria. It is striking that almost all of the 75 Enterobacteria species that have been sequenced contain sequences with very high degree of homology to the E. coli Gss protein. To find out the physiological significance of glutathionylspermidine in E. coli, we have performed global transcriptome analyses. The microarray studies comparing gss(+) and Δgss strains

SUBMITTER: Chattopadhyay MK 

PROVIDER: S-EPMC3812799 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature