Toll-like receptor 2 mediates microglia/brain macrophage MT1-MMP expression and glioma expansion.

ABSTRACT:

Background

Glioblastomas are the most aggressive primary brain tumors in humans. Microglia/brain macrophage accumulation in and around the tumor correlates with malignancy and poor clinical prognosis of these tumors. We have previously shown that microglia promote glioma expansion through upregulation of membrane type 1 matrix metalloprotease (MT1-MMP). This upregulation depends on signaling via the Toll-like receptor (TLR) adaptor molecule myeloid differentiation primary response gene 88 (MyD88).

Methods

Using in vitro, ex vivo, and in vivo techniques, we identified TLR2 as the main TLR controlling microglial MT1-MMP expression and promoting microglia-assisted glioma expansion.

Results

The implantation of mouse GL261 glioma cells into TLR2 knockout mice resulted in s

SUBMITTER: Vinnakota K 

PROVIDER: S-EPMC3813418 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature