Functional connectivity estimated from intracranial EEG predicts surgical outcome in intractable temporal lobe epilepsy.

ABSTRACT: This project aimed to determine if a correlation-based measure of functional connectivity can identify epileptogenic zones from intracranial EEG signals, as well as to investigate the prognostic significance of such a measure on seizure outcome following temporal lobe lobectomy. To this end, we retrospectively analyzed 23 adult patients with intractable temporal lobe epilepsy (TLE) who underwent an invasive stereo-EEG (SEEG) evaluation between January 2009 year and January 2012. A follow-up of at least one year was required. The primary outcome measure was complete seizure-freedom at last follow-up. Functional connectivity between two areas in the temporal lobe that were sampled by two SEEG electrode contacts was defined as Pearson's correlation coefficient of interictal activity between t

SUBMITTER: Antony AR 

PROVIDER: S-EPMC3813548 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature