Hot regions of noninterfering crossovers coexist with a nonuniformly interfering pathway in Arabidopsis thaliana.

ABSTRACT: In most organisms that have been studied, crossovers formed during meiosis exhibit interference: nearby crossovers are rare. Here we provide an in-depth study of crossover interference in Arabidopsis thaliana, examining crossovers genome-wide in >1500 backcrosses for both male and female meiosis. This unique data set allows us to take a two-pathway modeling approach based on superposing a fraction p of noninterfering crossovers and a fraction (1 - p) of interfering crossovers generated using the gamma model characterized by its interference strength nu. Within this framework, we fit the two-pathway model to the data and compare crossover interference strength between chromosomes and then along chromosomes. We find that the interfering pathway has markedly higher interference strength nu in

SUBMITTER: Basu-Roy S 

PROVIDER: S-EPMC3813863 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature