Autocatalytic-assisted photorelease of a sensitizer drug bound to a silica support.

ABSTRACT: The photorelease of a sensitizer from a fluorinated silica surface occurs by a reaction of singlet oxygen with the vinyl ether bond linker with scission of a dioxetane intermediate. Irradiation of the released sensitizer generates singlet oxygen, which accelerates the release of more sensitizer via an autocatalytic reaction. Sigmoidal behavior of sensitizer release in n-butanol and n-octanol occurs at an optimal temperature of 20 °C. The photorelease efficiency was reduced at low temperatures, where the sensitizer was retained on the surface due to a long-lived dioxetane with inefficient scission, and also reduced at high temperatures, due to a slower reaction of (1)O2 with the vinyl ether bond. Immediate acceleration is a result of released sensitizer being used as a dopant to eliminate t

SUBMITTER: Bartusik D 

PROVIDER: S-EPMC3814010 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature