Inflammatory and endothelial activation biomarkers and risk of sepsis: a nested case-control study.

ABSTRACT:

Purpose

Elevated biomarkers of inflammation and endothelial cell activation have been associated with severity of sepsis. We sought to determine the association between these baseline markers and subsequent episodes of sepsis.

Materials and methods

We performed a nested case-control analysis using subjects from the REasons for Geographic and Racial Differences in Stroke cohort. We compared 162 sepsis cases (hospitalized for a serious infection with ≥2 systemic inflammatory response syndrome criteria) with 162 nonsepsis controls (hospitalized for a serious infection but not sepsis) matched by age, sex, and observation time epoch. Using conditional logistic regression, we evaluated the associations between sepsis and baseline levels of interleukin-6 (IL-6), tumor necrosis fact

SUBMITTER: Wang HE 

PROVIDER: S-EPMC3814035 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature