Genomic correlates of relationship QTL involved in fore- versus hind limb divergence in mice.

ABSTRACT: Divergence of serially homologous elements of organisms is a common evolutionary pattern contributing to increased phenotypic complexity. Here, we study the genomic intervals affecting the variational independence of fore- and hind limb traits within an experimental mouse population. We use an advanced intercross of inbred mouse strains to map the loci associated with the degree of autonomy between fore- and hind limb long bone lengths (loci affecting the relationship between traits, relationship quantitative trait loci [rQTL]). These loci have been proposed to interact locally with the products of pleiotropic genes, thereby freeing the local trait from the variational constraint due to pleiotropic mutations. Using the known polymorphisms (single nucleotide polymorphisms [SNPs]) between th

SUBMITTER: Pavlicev M 

PROVIDER: S-EPMC3814202 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature