Condensin II subunit dCAP-D3 restricts retrotransposon mobilization in Drosophila somatic cells.

ABSTRACT: Retrotransposon sequences are positioned throughout the genome of almost every eukaryote that has been sequenced. As mobilization of these elements can have detrimental effects on the transcriptional regulation and stability of an organism's genome, most organisms have evolved mechanisms to repress their movement. Here, we identify a novel role for the Drosophila melanogaster Condensin II subunit, dCAP-D3 in preventing the mobilization of retrotransposons located in somatic cell euchromatin. dCAP-D3 regulates transcription of euchromatic gene clusters which contain or are proximal to retrotransposon sequence. ChIP experiments demonstrate that dCAP-D3 binds to these loci and is important for maintaining a repressed chromatin structure within the boundaries of the retrotransposon and for rep

SUBMITTER: Schuster AT 

PROVIDER: S-EPMC3814330 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature