Screening for cervical cancer precursors with p16/Ki-67 dual-stained cytology: results of the PALMS study.

ABSTRACT:

Background

Pap cytology is known to be more specific but less sensitive than testing for human papillomavirus (HPV) for the detection of high-grade cervical intraepithelial neoplasia (CIN2+). We assessed whether p16/Ki-67 dual-stained cytology, a biomarker combination indicative of transforming HPV infections, can provide high sensitivity for CIN2+ in screening while maintaining high specificity. Results were compared with Pap cytology and HPV testing.

Methods

A total of 27,349 women 18 years or older attending routine cervical cancer screening were prospectively enrolled in five European countries. Pap cytology, p16/Ki-67 immunostaining, and HPV testing were performed on all women. Positive test results triggered colposcopy referral, except for women younger than 30 years w

SUBMITTER: Ikenberg H 

PROVIDER: S-EPMC3814411 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature