Ontology highlight
ABSTRACT:
SUBMITTER: Bodor C
PROVIDER: S-EPMC3814734 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Blood 20130919 18
Gain of function mutations in the H3K27 methyltransferase EZH2 represent a promising therapeutic target in germinal center lymphomas. In this study, we assessed the frequency and distribution of EZH2 mutations in a large cohort of patients with follicular lymphoma (FL) (n = 366) and performed a longitudinal analysis of mutation during the disease progression from FL to transformed FL (tFL) (n = 33). Mutations were detected at 3 recurrent mutation hot spots (Y646, A682, and A692) in 27% of FL cas ...[more]