Noncalcified coronary atherosclerotic plaque and immune activation in HIV-infected women.

ABSTRACT:

Background

Little is known about coronary plaque in human immunodeficiency virus (HIV)-infected women.

Methods

Sixty HIV-infected and 30 non-HIV-infected women without symptoms or history of cardiovascular disease were recruited to assess coronary plaque with coronary computed tomographic angiography and immune activation. Data from 102 HIV-infected men and 41 non-HIV-infected male controls were compared.

Results

HIV-infected women demonstrated significantly higher percentages of segments with noncalcified plaque (mean ± SD, 74% ± 28% vs 23% ± 39% compared to female control subjects; median [interquartile range], 75% [63%-100%] vs 0% [0%-56%]; P = .007) and more segments with noncalcified plaque (mean ± SD, 0.92 ± 1.48 vs 0.40 ± 1.44; median [interquartile range], 0 [

SUBMITTER: Fitch KV 

PROVIDER: S-EPMC3814845 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature