A systems level predictive model for global gene regulation of methanogenesis in a hydrogenotrophic methanogen.

ABSTRACT: Methanogens catalyze the critical methane-producing step (called methanogenesis) in the anaerobic decomposition of organic matter. Here, we present the first predictive model of global gene regulation of methanogenesis in a hydrogenotrophic methanogen, Methanococcus maripaludis. We generated a comprehensive list of genes (protein-coding and noncoding) for M. maripaludis through integrated analysis of the transcriptome structure and a newly constructed Peptide Atlas. The environment and gene-regulatory influence network (EGRIN) model of the strain was constructed from a compendium of transcriptome data that was collected over 58 different steady-state and time-course experiments that were performed in chemostats or batch cultures under a spectrum of environmental perturbations that modulate

SUBMITTER: Yoon SH 

PROVIDER: S-EPMC3814884 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature