Proteins and lipids of glycosomal membranes from Leishmania tarentolae and Trypanosoma brucei.

ABSTRACT: In kinetoplastid protists, several metabolic pathways, including glycolysis and purine salvage, are located in glycosomes, which are microbodies that are evolutionarily related to peroxisomes. With the exception of some potential transporters for fatty acids, and one member of the mitochondrial carrier protein family, proteins that transport metabolites across the glycosomal membrane have yet to be identified. We show here that the phosphatidylcholine species composition of Trypanosoma brucei glycosomal membranes resembles that of other cellular membranes, which means that glycosomal membranes are expected to be impermeable to small hydrophilic molecules unless transport is facilitated by specialized membrane proteins. Further, we identified 464 proteins in a glycosomal membrane preparatio

SUBMITTER: Colasante C 

PROVIDER: S-EPMC3814921 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature