Community structure and antibiotic production of Streptomyces nodosus bioreactors cultured in liquid environments.

ABSTRACT: Immobilized bacteria are being assessed by industry for drug delivery, novel fermentation systems and the protection of organisms in harsh environments. Alginate bioreactors containing Streptomyces nodosus were examined for community structure, cell viability and amphotericin production under different growth conditions. When cell proliferation was encouraged, substrate hyphae were found inside the alginate matrix and within multicellular projections on the surface of the capsule. The periphery of these projections had erect and branched hyphae, morphologically identical to aerial hyphae. Antibiotic production from immobilized organisms was assessed using conditioned culture medium to eliminate the emergence of a free-dwelling population. These organisms sporulated with reduced antibiotic

SUBMITTER: Pereira T 

PROVIDER: S-EPMC3815244 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature