Barriers to a cure for HIV: new ways to target and eradicate HIV-1 reservoirs.

ABSTRACT: Antiretroviral therapy for HIV infection needs lifelong access and strict adherence to regimens that are both expensive and associated with toxic effects. A curative intervention will be needed to fully stop the epidemic. The failure to eradicate HIV infection during long-term antiretroviral therapy shows the intrinsic stability of the viral genome in latently infected CD4T cells and other cells, and possibly a sustained low-level viral replication. Heterogeneity in latently infected cell populations and homoeostatic proliferation of infected cells might affect the dynamics of virus production and persistence. Despite potent antiretroviral therapy, chronic immune activation, inflammation, and immune dysfunction persist, and are likely to have important effects on the size and distribution

SUBMITTER: Katlama C 

PROVIDER: S-EPMC3815451 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature