Mesenchymal stem cells for the sustained in vivo delivery of bioactive factors.

ABSTRACT: Mesenchymal stem cells (MSC) are a promising tool for cell therapy, either through direct contribution to the repair of bone, tendon and cartilage or as an adjunct therapy through protein production and immune mediation. They are an attractive vehicle for cellular therapies due to a variety of cell intrinsic and environmentally responsive properties. Following transplantation, MSC are capable of systemic migration, are not prone to tumor formation, and appear to tolerize the immune response across donor mismatch. These attributes combine to allow MSC to reside in many different tissue types without disrupting the local microenvironment and, in some cases, responding to the local environment with appropriate protein secretion. We describe work done by our group and others in using human MSC

SUBMITTER: Meyerrose T 

PROVIDER: S-EPMC3815452 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature