A practical method for the synthesis of highly enantioenriched trans-1,2-amino alcohols.

ABSTRACT: A highly enantioselective addition of phenyl carbamate to meso-epoxides has been developed to efficiently generate protected trans-1,2-amino alcohols. This transformation is promoted by an oligomeric (salen)Co-OTf catalyst and has been used to prepare two useful 2-aminocycloalkanol hydrochlorides in enantiopure form on a multigram scale from commercially available starting materials.

SUBMITTER: Birrell JA 

PROVIDER: S-EPMC3815482 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature