Differential impact of β and γ residue preorganization on α/β/γ-peptide helix stability in water.

ABSTRACT: Cyclic constraints have proven to be very effective for preorganizing β-amino acid residues and thereby stabilizing β- and α/β-peptide helices, but little is known about possible preorganization effects among γ residues. Here we assess and compare the impact of cyclic preorganization of β and γ residues in the context of a specific α/β/γ-peptide helix. The results show that β residue preorganization is critical for helix stability but that γ residue preorganization is less important.

SUBMITTER: Shin YH 

PROVIDER: S-EPMC3815483 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature