Evaluation of memory endophenotypes for association with CLU, CR1, and PICALM variants in black and white subjects.

ABSTRACT:

Background

Genetic variants at the CLU, CR1, and PICALM loci associate with risk for late-onset Alzheimer's disease (LOAD) in genomewide association studies. In this study, our aim was to determine whether the LOAD risk variants at these three loci influence memory endophenotypes in black and white subjects.

Methods

We pursued an association study between single nucleotide polymorphism genotypes at the CLU, CR1, and PICALM loci and memory endophenotypes. We assessed black subjects (AA series: 44 with LOAD and 224 control subjects) recruited at Mayo Clinic Florida and whites recruited at Mayo Clinic Minnesota (RS series: 372 with LOAD and 1690 control subjects) and Florida (JS series: 60 with LOAD and 529 control subjects). Single nucleotide polymorphisms at the LOAD risk loc

SUBMITTER: Pedraza O 

PROVIDER: S-EPMC3815516 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature