Articular osteochondrosis: a comparison of naturally-occurring human and animal disease.

ABSTRACT:

Background

Osteochondrosis (OC) is a common developmental orthopedic disease affecting both humans and animals. Despite increasing recognition of this disease among children and adolescents, its pathogenesis is incompletely understood because clinical signs are often not apparent until lesions have progressed to end-stage, and examination of cadaveric early lesions is not feasible. In contrast, both naturally-occurring and surgically-induced animal models of disease have been extensively studied, most notably in horses and swine, species in which OC is recognized to have profound health and economic implications. The potential for a translational model of human OC has not been recognized in the existing human literature.

Objective

The purpose of this review is to highlight t

SUBMITTER: McCoy AM 

PROVIDER: S-EPMC3815567 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature