Fibronectin is essential for reparative cardiac progenitor cell response after myocardial infarction.

ABSTRACT:

Rationale

Adoptive transfer of cardiac progenitor cells (CPCs) has entered clinical application, despite limited mechanistic understanding of the endogenous response after myocardial infarction (MI). Extracellular matrix undergoes dramatic changes after MI and therefore might be linked to CPC-mediated repair.

Objective

To demonstrate the significance of fibronectin (Fn), a component of the extracellular matrix, for induction of the endogenous CPC response to MI.

Methods and results

This report shows that presence of CPCs correlates with the expression of Fn during cardiac development and after MI. In vivo, genetic conditional ablation of Fn blunts CPC response measured 7 days after MI through reduced proliferation and diminished survival. Attenuated vasculogenesis and

SUBMITTER: Konstandin MH 

PROVIDER: S-EPMC3815660 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature