Analgesic use and the risk of kidney cancer: a meta-analysis of epidemiologic studies.

ABSTRACT: Analgesics are the most commonly used over-the-counter drugs worldwide with certain analgesics having cancer prevention effect. The evidence for an increased risk of developing kidney cancer with analgesic use is mixed. Using a meta-analysis design of available observational epidemiologic studies, we investigated the association between analgesic use and kidney cancer risk. We searched the MEDLINE and EMBASE databases to identify eligible case-control or cohort studies published in English until June 2012 for three categories of analgesics: acetaminophen, aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs). Study-specific effect estimates were pooled to compute an overall relative risk (RR) and its 95% confidence interval (CI) using a random-effects model for each category of t

SUBMITTER: Choueiri TK 

PROVIDER: S-EPMC3815746 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature