Ontology highlight
ABSTRACT:
SUBMITTER: Ong CT
PROVIDER: S-EPMC3816015 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Ong Chin-Tong CT Van Bortle Kevin K Ramos Edward E Corces Victor G VG
Cell 20130919 1
Insulators mediate inter- and intrachromosomal contacts to regulate enhancer-promoter interactions and establish chromosome domains. The mechanisms by which insulator activity can be regulated to orchestrate changes in the function and three-dimensional arrangement of the genome remain elusive. Here, we demonstrate that Drosophila insulator proteins are poly(ADP-ribosyl)ated and that mutation of the poly(ADP-ribose) polymerase (Parp) gene impairs their function. This modification is not essentia ...[more]