Genome-wide association study of survival in patients with pancreatic adenocarcinoma.

ABSTRACT:

Background and objective

Survival of patients with pancreatic adenocarcinoma is limited and few prognostic factors are known. We conducted a two-stage genome-wide association study (GWAS) to identify germline variants associated with survival in patients with pancreatic adenocarcinoma.

Methods

We analysed overall survival in relation to single nucleotide polymorphisms (SNPs) among 1005 patients from two large GWAS datasets, PanScan I and ChinaPC. Cox proportional hazards regression was used in an additive genetic model with adjustment for age, sex, clinical stage and the top four principal components of population stratification. The first stage included 642 cases of European ancestry (PanScan), from which the top SNPs (p≤10(-5)) were advanced to a joint analysis with 363 ad

SUBMITTER: Wu C 

PROVIDER: S-EPMC3816124 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature