Association between vitamin D metabolism gene polymorphisms and risk of islet autoimmunity and progression to type 1 diabetes: the diabetes autoimmunity study in the young (DAISY).

ABSTRACT:

Context

Vitamin D metabolism genes have been associated with type 1 diabetes (T1D) risk; however, these genes have not been investigated for association with the preclinical phase of T1D, islet autoimmunity (IA). Studies of vitamin D metabolism genes may elucidate the role of vitamin D in complex diseases.

Objective

The objective of the study was to explore the association between seven vitamin D metabolism gene single-nucleotide polymorphisms (SNPs) and the risk of IA and progression to T1D.

Design

The Diabetes Autoimmunity Study in the Young is a longitudinal, observational study.

Setting

Newborn screening for human leukocyte antigen, sibling and offspring recruitment, and follow-up took place in Denver, Colorado.

Participants

A total of 1708 children

SUBMITTER: Frederiksen BN 

PROVIDER: S-EPMC3816262 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature