Blood pressure components and decline in kidney function in community-living older adults: the Cardiovascular Health Study.

ABSTRACT:

Background

Although hypertension contributes to kidney dysfunction in the general population, the contributions of elevated systolic blood pressure (SBP), diastolic blood pressure (DBP), and pulse pressure (PP) to kidney function decline in community-dwelling older adults are unknown.

Methods

We used linear and logistic regression to examine the separate and combined associations of SBP, DBP, and PP at baseline with kidney function decline among 4,365 older adults in the Cardiovascular Health Study. We used cystatin C to estimate glomerular filtration rate on 3 occasions over 7 years of follow-up. We defined rapid decline ≥ 3ml/min/year.

Results

Average age was 72.2 and mean (standard deviation) SBP, DBP, and PP were 135 (21), 71 (11), and 65 (18) mm Hg, respectively.

SUBMITTER: Rifkin DE 

PROVIDER: S-EPMC3816322 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature