Association of adiposity genetic variants with menarche timing in 92,105 women of European descent.

ABSTRACT: Obesity is of global health concern. There are well-described inverse relationships between female pubertal timing and obesity. Recent genome-wide association studies of age at menarche identified several obesity-related variants. Using data from the ReproGen Consortium, we employed meta-analytical techniques to estimate the associations of 95 a priori and recently identified obesity-related (body mass index (weight (kg)/height (m)(2)), waist circumference, and waist:hip ratio) single-nucleotide polymorphisms (SNPs) with age at menarche in 92,116 women of European descent from 38 studies (1970-2010), in order to estimate associations between genetic variants associated with central or overall adiposity and pubertal timing in girls. Investigators in each study performed a separate analysis

SUBMITTER: Fernandez-Rhodes L 

PROVIDER: S-EPMC3816344 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature