Second solid cancers after radiation therapy: a systematic review of the epidemiologic studies of the radiation dose-response relationship.

ABSTRACT: Rapid innovations in radiation therapy techniques have resulted in an urgent need for risk projection models for second cancer risks from high-dose radiation exposure, because direct observation of the late effects of newer treatments will require patient follow-up for a decade or more. However, the patterns of cancer risk after fractionated high-dose radiation are much less well understood than those after lower-dose exposures (0.1-5 Gy). In particular, there is uncertainty about the shape of the dose-response curve at high doses and about the magnitude of the second cancer risk per unit dose. We reviewed the available evidence from epidemiologic studies of second solid cancers in organs that received high-dose exposure (>5 Gy) from radiation therapy where dose-response curves were estima

SUBMITTER: Berrington de Gonzalez A 

PROVIDER: S-EPMC3816386 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature