WU and KI polyomavirus infections in pediatric hematology/oncology patients with acute respiratory tract illness.

ABSTRACT:

Background

WU and KI polyomaviruses (PyV) were discovered in 2007 in respiratory tract samples in adults and children. Other polyomaviruses (BKPyV and JCPyV) have been associated with illness in immunocompromised patients, and some studies suggest a higher prevalence of WUPyV and KIPyV in this population.

Objective

To determine whether a higher prevalence or viral load for WUPyV and KIPyV exists in immunocompromised children compared with immunocompetent children.

Study design

We measured the prevalence and viral load of WU and KI PyV by quantitative real-time PCR of viral DNA in respiratory tract specimens from pediatric hematology/oncology patients and immunocompetent controls with acute respiratory illnesses.

Results

The prevalence of WUPyV in the immunocomp

SUBMITTER: Rao S 

PROVIDER: S-EPMC3816538 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature